The circadian system actively synchronizes the temporal sequence of biological functions
with the environment. The oscillatory behavior of the system ensures that entrainment is not …

Environmental temperature strongly affects physiology of ectotherms. Small ectotherms, like
Drosophila, cannot endogenously regulate body temperature so must rely on behavior to …

We present a computational model for the mammalian circadian clock based on the
intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and …

Environmental time cues, such as photocycles (light/dark) and thermocycles (warm/cold),
synchronize (entrain) endogenous biological clocks to local time. Although much is known …

Zebrafish has become one of the most important animal models in research. Most of the
variables studied using zebrafish are influenced by water temperature. The objective of this …

The core mechanism of circadian timekeeping in arthropods and vertebrates consists of
feedback loops involving several clock genes, including period (per) and timeless (tim),. In …

The brain of Drosophila melanogaster contains∼ 150 circadian neurons [1] functionally
divided into morning and evening cells that control peaks in daily behavioral activity at dawn …

Background: Circadian clocks are synchronized by both light: dark cycles and by
temperature fluctuations. Although it has long been known that temperature cycles can …

Background Many ectotherms, including C. elegans, have shorter life spans at high
temperature than at low temperature. High temperature is generally thought to increase the" …

Circadian clocks are aligned to the environment via synchronizing signals, or Zeitgebers,
such as daily light and temperature cycles, food availability, and social behavior. In this …