3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …
organized crypt–villus characteristics. This unique structure is necessary to maintain …
[HTML][HTML] Patient-specific organoid and organ-on-a-chip: 3D cell-culture meets 3D printing and numerical simulation
The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …
architecture and function of living organs or tissues and contribute immensely to advances in …
On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease
This protocol describes the design, fabrication and use of a 3D physiological and
pathophysiological motor unit model consisting of motor neurons coupled to skeletal …
pathophysiological motor unit model consisting of motor neurons coupled to skeletal …
Organs-on-Chips platforms are everywhere: A zoom on biomedical investigation
M Zommiti, N Connil, A Tahrioui, A Groboillot, C Barbey… - Bioengineering, 2022 - mdpi.com
Over the decades, conventional in vitro culture systems and animal models have been used
to study physiology, nutrient or drug metabolisms including mechanical and …
to study physiology, nutrient or drug metabolisms including mechanical and …
Microfluidic based human-on-a-chip: A revolutionary technology in scientific research
S Syama, PV Mohanan - Trends in Food Science & Technology, 2021 - Elsevier
Background Detrimental drug toxicity and failure in efficacy during clinical trials is one of the
major hurdles faced by the pharmaceutical companies. Conventionally, preclinical safety …
major hurdles faced by the pharmaceutical companies. Conventionally, preclinical safety …
Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS)
Recent advances in organ-on-a-chip technology have resulted in numerous examples of
microscale systems that faithfully mimic the physiology and pathology of human organs and …
microscale systems that faithfully mimic the physiology and pathology of human organs and …
Microneedles in advanced microfluidic systems: A systematic review throughout lab and organ-on-a-chip applications
Microneedles (MNs) have been widely used in biomedical applications for drug delivery and
biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to …
biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to …
Organ-on-a-chip technology: turning its potential for clinical benefit into reality
M Haddrick, PB Simpson - Drug discovery today, 2019 - Elsevier
Highlights•Organ-on-a-chip technology has the potential to improve the success of drug
discovery.•Environmental cues and inter-organ communication increase physiological …
discovery.•Environmental cues and inter-organ communication increase physiological …
Mimicking the human physiology with microphysiological systems (MPS)
Microphysiological systems (MPS), also known as organ-on-a-chip technology, combine cell
culture models and microtechnology to mimic tissue microenvironment and provide …
culture models and microtechnology to mimic tissue microenvironment and provide …
A progress report and roadmap for microphysiological systems and Organ-On-A-Chip technologies to be more predictive models in human (Knee) osteoarthritis
M Rothbauer, EI Reihs, A Fischer… - … in Bioengineering and …, 2022 - frontiersin.org
Osteoarthritis (OA), a chronic debilitating joint disease affecting hundreds of million people
globally, is associated with significant pain and socioeconomic costs. Current treatment …
globally, is associated with significant pain and socioeconomic costs. Current treatment …