Estrogen receptor mutations and functional consequences for breast cancer
C Thomas, JÅ Gustafsson - Trends in Endocrinology & Metabolism, 2015 - cell.com
A significant number of estrogen receptor α (ERα)-positive breast tumors develop resistance
to endocrine therapy and recur with metastatic disease. Several mechanisms of endocrine …
to endocrine therapy and recur with metastatic disease. Several mechanisms of endocrine …
Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast …
K Hudson, UJ Hancox, C Trigwell, R McEwen… - Molecular cancer …, 2016 - AACR
The PIK3CA gene, encoding the p110α catalytic unit of PI3Kα, is one of the most frequently
mutated oncogenes in human cancer. Hence, PI3Kα is a target subject to intensive efforts in …
mutated oncogenes in human cancer. Hence, PI3Kα is a target subject to intensive efforts in …