Infectious diseases are one of the most intimidating threats to human race, responsible for
an immense burden of disabilities and deaths. Rapid diagnosis and treatment of infectious …

The emergence of the new coronavirus 2019 (COVID-19) was first seen in December 2019,
which has spread rapidly and become a global pandemic. The number of cases of COVID …

Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …

Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …

Background A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+
leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and …

In recent years, the CRISPR/Cas9-based gene-editing techniques have been well
developed and applied widely in several aspects of research in the biological sciences, in …

The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …

From its unexpected discovery as a bacterial adaptive immune system to its countless
applications as one of the most versatile gene-editing tools, the CRISPR/Cas9 system has …

Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of
CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes …

Background: During the past 35 years, highly effective ART has saved the lives of millions of
people worldwide by suppressing viruses to undetectable levels. However, this does not …