Decoding the organization of spinal circuits that control locomotion

O Kiehn - Nature Reviews Neuroscience, 2016 - nature.com
Unravelling the functional operation of neuronal networks and linking cellular activity to
specific behavioural outcomes are among the biggest challenges in neuroscience. In this …

The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord

BJ Schmidt, LM Jordan - Brain research bulletin, 2000 - Elsevier
Over the past 40 years, much has been learned about the role of serotonin in spinal cord
reflex modulation and locomotor pattern generation. This review presents an historical …

A cluster of cholinergic premotor interneurons modulates mouse locomotor activity

L Zagoraiou, T Akay, JF Martin, RM Brownstone… - Neuron, 2009 - cell.com
Mammalian motor programs are controlled by networks of spinal interneurons that set the
rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive …

Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion

IA Rybak, NA Shevtsova… - The Journal of …, 2006 - Wiley Online Library
The mammalian spinal cord contains a locomotor central pattern generator (CPG) that can
produce alternating rhythmic activity of flexor and extensor motoneurones in the absence of …

Physiological, anatomical and genetic identification of CPG neurons in the developing mammalian spinal cord

O Kiehn, SJB Butt - Progress in neurobiology, 2003 - Elsevier
The basic motor patterns underlying rhythmic limb movements during locomotion are
generated by neuronal networks located within the spinal cord. These networks are called …

Expression of vesicular glutamate transporters in rat lumbar spinal cord, with a note on dorsal root ganglia

M Landry, R Bouali‐Benazzouz… - Journal of …, 2004 - Wiley Online Library
Three vesicular glutamate transporters (VGLUTs) have been recently identified and their
distribution has been mapped in various brain areas. In the present study, we used …

Locomotor-like rhythms in a genetically distinct cluster of interneurons in the mammalian spinal cord

CA Hinckley, R Hartley, L Wu, A Todd… - Journal of …, 2005 - journals.physiology.org
Electrophysiological and morphological properties of genetically identified spinal
interneurons were examined to elucidate their possible contribution to locomotor-like …

Firing properties of identified interneuron populations in the mammalian hindlimb central pattern generator

SJB Butt, RM Harris-Warrick, O Kiehn - Journal of Neuroscience, 2002 - Soc Neuroscience
Little is known about the network structure of the central pattern generator (CPG) controlling
locomotor movements in mammals. The present experiments aim at providing such …

Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord

O Kiehn, O Kjaerulff, MC Tresch… - Brain research bulletin, 2000 - Elsevier
Motor neurons are endowed with intrinsic and conditional membrane properties that may
shape the final motor output. In the first half of this paper we present data on the contribution …

Identification, localization, and modulation of neural networks for walking in the mudpuppy (Necturus maculatus) spinal cord

J Cheng, RB Stein, K Jovanovic, K Yoshida… - Journal of …, 1998 - Soc Neuroscience
We tested the hypothesis that the neural networks for walking in the mudpuppy can be
divided into a flexor and an extensor center, each of which contains collections of …