T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …

Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

T cells are important for effective viral clearance, elimination of virus-infected cells, and long-
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …

Several current immunotherapy approaches target private neoantigens derived from
mutations that are unique to individual patients' tumors. However, immunotherapeutic …

CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is
known about the interplay between responses and its impact on T cell function and tumor …

Adaptive immune system uses T cell receptors (TCRs) to recognize pathogens and to
consequently initiate immune responses. TCRs can be sequenced from individuals and …

T cell recognition of specific antigens mediates protection from pathogens and controls
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …

T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …

Deciphering immune recognition is critical for understanding a broad range of diseases and
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …