[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Mitochondrial heterogeneity and homeostasis through the lens of a neuron

G Pekkurnaz, X Wang - Nature metabolism, 2022 - nature.com
Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

The cytoplasmic dynein transport machinery and its many cargoes

SL Reck-Peterson, WB Redwine, RD Vale… - … reviews Molecular cell …, 2018 - nature.com
Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Mitochondria, energy, and metabolism in neuronal health and disease

D Trigo, C Avelar, M Fernandes, J Sá… - FEBS …, 2022 - Wiley Online Library
Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

Mitochondrial structure and bioenergetics in normal and disease conditions

M Protasoni, M Zeviani - International journal of molecular sciences, 2021 - mdpi.com
Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Axonal transport: cargo-specific mechanisms of motility and regulation

S Maday, AE Twelvetrees, AJ Moughamian… - Neuron, 2014 - cell.com
Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …

Mitochondrial quality control and disease: insights into ischemia-reperfusion injury

AR Anzell, R Maizy, K Przyklenk, TH Sanderson - Molecular neurobiology, 2018 - Springer
Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …

Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases

L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Mitochondria as a therapeutic target for ischemic stroke

Z He, N Ning, Q Zhou, SE Khoshnam… - Free Radical Biology and …, 2020 - Elsevier
Stroke is the leading cause of death and physical disability worldwide. Mitochondrial
dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes …

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

MH Yan, X Wang, X Zhu - Free Radical Biology and Medicine, 2013 - Elsevier
Alzheimer disease (AD) and Parkinson disease (PD) are the two most common age-related
neurodegenerative diseases characterized by prominent neurodegeneration in selective …