Osteoarthritis is a common age-related joint degenerative disease. Pain, swelling, brief
morning stiffness, and functional limitations are its main characteristics. There are still no …

Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral
ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces …

Ischemic stroke (IS) is a common neurological disorder associated with high disability rates
and mortality rates. At present, recombinant tissue plasminogen activator (r-tPA) is the only …

Stroke ranks second as a leading cause of death and permanent disability globally.
Microglia, innate immune cells in the brain, respond rapidly to ischemic injury, triggering a …

Background Exercise preconditioning (EP) is essential for preventing ischemic stroke.
Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia …

Stroke, especially ischemic stroke, is an important cause of neurological morbidity and
mortality worldwide. Growing evidence suggests that the immune system plays an intricate …

Chronic pain is a notable health concern because of its prevalence, persistence, and
associated mental stress. Drugs targeting chronic pain with potent abirritation, and minimal …

Morin is a bioactive flavonoid with prominent neuroprotective potentials, however, its impact
on epilepsy-provoked cognitive dysregulations has not been revealed. Hence, the present …

Based on the current results, they showed that Schisandra chinensis lignans (SCL)
ameliorated depressive-like behaviors in chronic unpredictable mild stress (CUMS) mice …

Recent evidence suggests that misfolding, clumping, and accumulation of proteins in the
brain may be common causes and pathogenic mechanism for several neurological …