The glymphatic system (en) during inflammation

FLH Mogensen, C Delle, M Nedergaard - International journal of …, 2021 - mdpi.com
The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

The Ocular Glymphatic System—Current Understanding and Future Perspectives

C Delle, X Wang, M Nedergaard - International Journal of Molecular …, 2024 - mdpi.com
The ocular glymphatic system subserves the bidirectional polarized fluid transport in the
optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces …

Design, Characterization and Pharmacokinetic–Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of …

PS Rawat, PR Ravi, SI Mir, MS Khan, H Kathuria… - Pharmaceutics, 2023 - mdpi.com
This study developed a dual-responsive in situ gel of nebivolol (NEB), a selective β-
adrenergic antagonist. The gel could achieve sustained concentrations in the aqueous …

A portable feedback-controlled pump for monitoring eye outflow facility in conscious rats

Y Mohamed, CL Passaglia - Plos one, 2023 - journals.plos.org
Intraocular pressure (IOP) is heavily influenced by the resistance of trabecular outflow
pathways through which most of the aqueous humor produced by the eye continuously …

International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs

IM Pruimboom‐Brees, S Gupta… - Clinical and …, 2023 - Wiley Online Library
The eye, which is under constant exposure to environmental pathogens, has evolved
various anatomic and immunological barriers critical to the protection of tissues lacking …

Ocular hyperemia associated with topical glaucoma medication: understanding and differentiating clinical appearance and underlying mechanisms

G Holló - Expert Opinion on Drug Safety, 2024 - Taylor & Francis
Introduction Adherence to therapy is fundamental for glaucoma management. Side effects of
topical intraocular pressure (IOP)-lowering medications must be managed effectively to …

Redefined Formula for Anterior Chamber Volume Calculation: Quantitative Analysis of Biometric Parameters Across Ocular Pathologies

A Zemitis, V Rizzuto, D Lavrinovica, J Vanags… - Clinical …, 2024 - Taylor & Francis
Purpose This study evaluates the discrepancies between ACV measurements obtained from
the Heidelberg Anterion and Zeiss IOLMaster 700 and investigates the significance of ACV …

Chemical Insights into Topical Agents in Intraocular Pressure Management: From Glaucoma Etiopathology to Therapeutic Approaches

GN Patton, HJ Lee - Pharmaceutics, 2024 - mdpi.com
Glaucoma encompasses a group of optic neuropathies characterized by complex and often
elusive etiopathology, involvihttng neurodegeneration of the optic nerve in conjunction with …

Risk factors and prognostic factors associated with retinal detachment and visual outcomes in acute retinal necrosis

Y Li, L Chen, P Li, H Kang, Y Tao - BMC ophthalmology, 2024 - Springer
Objective To investigate the risk factors and prognostic factors that affect the long-term
clinical outcomes of acute retinal necrosis (ARN). Methods A retrospective study of patients …

Segmental Unconventional Outflow in Mouse Eyes

HL Li, R Ren, H Gong - Investigative Ophthalmology & Visual …, 2023 - iovs.arvojournals.org
Purpose: To investigate the flow pattern in unconventional outflow and its correlation with
conventional outflow in mouse eyes. Methods: Fluorescent microspheres were injected into …