Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

The jumonji (JMJ) family of histone demethylases are Fe2+-and α-ketoglutarate-dependent
oxygenases that are essential components of regulatory transcriptional chromatin …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R
(−)‐2‐hydroxyglutarate (R‐2HG) accumulation. By using biochemical, structural and cellular …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

INTRODUCTION Natural posttranslational modifications (PTMs) to proteins expand the
chemical groups available to proteins. The ability to expand posttranslational functional …