Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

The Wnt signaling pathways are a group of signal transduction pathways that play an
important role in cell fate specification, cell proliferation and cell migration. Aberrant …

Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in
cancer biology. This chapter summarizes the research that provides a proof of concept for …

Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …

Glioblastoma multiformes (GBMs) are extensively heterogeneous at both cellular and
molecular levels. Current therapeutic strategies include targeting of key signaling molecules …

The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal
and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter …

Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

Restoring sodium iodide symporter (NIS) expression and function remains a major
challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient …

We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of
radioiodine in neuroblastoma tumors after systemic nonviral polyplex-mediated sodium …

The tumor-homing property of mesenchymal stem cells (MSCs) allows targeted delivery of
therapeutic genes into the tumor microenvironment. The application of sodium iodide …