Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …

Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed
cell death known as cornification. Cornification leads to the formation of the outermost skin …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

Abstract Goll, Darrel E., Valery F. Thompson, Hongqi Li, Wei Wei, and Jinyang Cong. The
Calpain System. Physiol Rev 83: 731–801, 2003; 10.1152/physrev. 00029.2002.—The …

The calpains are a conserved family of cysteine proteinases that catalyse the controlled
proteolysis of many specific substrates. Calpain activity is implicated in several fundamental …

The calpain family of proteases has been implicated in cellular processes such as
apoptosis, proliferation and cell migration. Calpains are involved in several key aspects of …

Variation in the calpain 10 gene has recently been shown to be associated with type 2
diabetes by positional cloning. Since then, studies on calpain 10 have been started in …

The number of mammalian calpain protease family members has grown to 14 on last count.
Overactivation of calpain 1 and calpain 2 (and their small subunit) has long been tied to …

The objective of this investigation was to test the hypothesis that-calpain is largely
responsible for postmortem proteolysis of muscle proteins. To accomplish this objective, we …