Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation

D Brites, A Fernandes - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Patients with chronic inflammation are often associated with the emergence of depression
symptoms, while diagnosed depressed patients show increased levels of circulating …

[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

Epigenetic inheritance: concepts, mechanisms and perspectives

I Lacal, R Ventura - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Parents' stressful experiences can influence an offspring's vulnerability to many pathological
conditions, including psychopathologies, and their effects may even endure for several …

Dissecting early life stress-induced adolescent depression through epigenomic approach

S Ochi, Y Dwivedi - Molecular psychiatry, 2023 - nature.com
Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity

O Issler, S Haramati, ED Paul, H Maeno, I Navon… - Neuron, 2014 - cell.com
The link between dysregulated serotonergic activity and depression and anxiety disorders is
well established, yet the molecular mechanisms underlying these psychopathologies are not …

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Genetic contributions of inflammation to depression

J Barnes, V Mondelli, CM Pariante - Neuropsychopharmacology, 2017 - nature.com
This paper describes the effects of immune genes genetic variants and mRNA expression
on depression's risk, severity, and response to antidepressant treatment, through a …

Low-grade inflammation as a predictor of antidepressant and anti-inflammatory therapy response in MDD patients: a systematic review of the literature in combination …

G Arteaga-Henríquez, MS Simon, B Burger… - Frontiers in …, 2019 - frontiersin.org
Low-grade inflammation plays a role not only in the pathogenesis of major depressive
disorder (MDD) but probably also in the poor responsiveness to regular antidepressants …

MicroRNAs and exosomes in depression: potential diagnostic biomarkers

J Tavakolizadeh, K Roshanaei… - Journal of Cellular …, 2018 - Wiley Online Library
Depression is known as one of important psychiatric disorders which could be associated
with disability among various populations. Diagnostic and statistical manual of mental …

[HTML][HTML] MicroRNA and posttranscriptional dysregulation in psychiatry

M Geaghan, MJ Cairns - Biological psychiatry, 2015 - Elsevier
Psychiatric syndromes, including schizophrenia, mood disorders, and autism spectrum
disorders, are characterized by a complex range of symptoms, including psychosis …