Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …

Voltage-gated potassium (Kv) channels from the Kv4, or Shal-related, gene family underlie a
major component of the A-type potassium current in mammalian central neurons. We …

Objectives: The aim of the present study was to compare the apico–basal distribution of ion
currents and the underlying ion channel proteins in canine and human ventricular …

The transient outward current (Ito), an important contributor to transmural
electrophysiological heterogeneity, is significantly remodelled in congestive heart failure …

Background—Brugada syndrome (BrS) has a significantly higher incidence among the male
sex. Among genes coding ion channels and their modulatory proteins, KCNE5 (KCNE1L) is …

Kv4. 3 encodes the pore‐forming subunit of the cardiac transient outward potassium current
(I to). hKv4. 3‐encoded current does not fully replicate cardiac I to, suggesting a functionally …

Heart failure (HF) is associated with reduced cardiac Na+ channel (SCN5A) current. We
hypothesized that abnormal transcriptional regulation of this ion channel during HF could …

We have used dye fills and electrophysiological recordings to identify and characterize a
cluster of motor neurons in the third instar larval ventral ganglion. This cluster of neurons is …

The Ca 2+-binding proteins KChIP1–4 (KChIP3 is also known as DREAM and calsenilin) act
as auxiliary subunits for voltage-gated K+ channels in the Kv4 family. Here we identify three …