The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …

In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

The type I interferon (IFN) response protects cells from viral infection by inducing hundreds
of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors …

Interferons (IFNs) exert their anti-viral effects by inducing the expression of hundreds of IFN-
stimulated genes (ISGs). The activity of known ISGs is insufficient to account for the …

Highlights•Individual ISGs have measurable phenotypes in vivo.•ISGs control viral
pathogenesis through a variety of mechanisms.•ISG effects in vivo are often virus-specific …

Our prevailing view of vertebrate host defense is strongly shaped by the notion of a
specialized set of immune cells as sole guardians of antimicrobial resistance. Yet this view …

Human immunodeficiency virus type 1 (HIV-1) interactions with myeloid dendritic cells (DCs)
can result in virus dissemination to CD4+ T cells via a trans infection pathway dependent on …

Induction of type I interferon (IFN) in response to microbial pathogens depends on a
conserved cGAS-STING signaling pathway. The presence of DNA in the cytoplasm activates …