Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

S Durdagi, Ç Dağ, B Dogan, M Yigin, T Avsar… - Structure, 2021 - cell.com
The COVID-19 pandemic has resulted in 198 million reported infections and more than 4
million deaths as of July 2021 (covid19. who. int). Research to identify effective therapies for …

Abnormal cholesterol metabolism and lysosomal dysfunction induce age-related hearing loss by inhibiting mTORC1-TFEB-dependent autophagy

YY Lee, J Ha, YS Kim, S Ramani, S Sung… - International Journal of …, 2023 - mdpi.com
Cholesterol is a risk factor for age-related hearing loss (ARHL). However, the effect of
cholesterol on the organ of Corti during the onset of ARHL is unclear. We established a …

[HTML][HTML] Atorvastatin prevents hearing impairment in the presence of hyperlipidemia

YY Lee, O Choo, YJ Kim, ES Gil, JH Jang… - … et Biophysica Acta (BBA …, 2020 - Elsevier
It is known that hyperlipidemia is a risk factor for sensorineural hearing loss. However, the
biological mechanisms underlying hyperlipidemia and hearing impairment have not been …

[HTML][HTML] Effect of statin on age-related hearing loss via drug repurposing

OS Choo, YY Lee, YS Kim, YJ Kim, DH Lee… - … Et Biophysica Acta (BBA …, 2022 - Elsevier
Hearing loss in the elderly cause communication difficulties, decreased quality of life,
isolation, loneliness and frustration. The aim of our study was to investigate the effect of drug …

Toward personalized diagnosis and therapy for hearing loss: insights from Cochlear implants

V Sagi, KM Stankovic - Otology & Neurotology, 2022 - journals.lww.com
Sensorineural hearing loss (SNHL) is the most common sensory deficit, disabling nearly half
a billion people worldwide. The cochlear implant (CI) has transformed the treatment of …

Association between statin use and sensorineural hearing loss in type 2 diabetic patients: a hospital-based study

HW Han, J Yee, YH Park, HS Gwak - Pharmaceuticals, 2021 - mdpi.com
Statins have emerged as protective agents against sensorineural hearing loss (SNHL)
associated with dyslipidemia, but the effects of statins on SNHL are not consistent. The …

Analysis of Characteristics and Prognostic Factors of Full-Frequency Idiopathic Sudden Sensorineural Hearing Loss with Hyperlipidemia

F Qin, M Wang, J Qiu, J Guo - International Journal of General …, 2024 - Taylor & Francis
Purpose To explore the relationship between hyperlipidemia and full-frequency idiopathic
sudden sensorineural hearing loss (FFHL). Patients and Methods A total of 145 FFHL …

Near-physiological-temperature serial femtosecond X-ray crystallography reveals novel conformations of SARS-CoV-2 main protease active site for improved drug …

S Durdagi, C Dag, B Dogan, M Yigin, T Avsar… - bioRxiv, 2020 - biorxiv.org
The COVID19 pandemic has resulted in 25+ million reported infections and nearly 850.000
deaths. Research to identify effective therapies for COVID19 includes: i) designing a vaccine …

Correlates of Hearing Impairment in the Health and Retirement Study

JR Smilowitz - 2024 - search.proquest.com
Abstract Background and Objectives: Hearing impairment (HI) is one of the most common
disabilities in older adults. This study examined the descriptive epidemiology and functional …

Drug Repurposing for, ENT and Head and Neck, Infectious and Oncologic Diseases: Current Practices and Future Possibilities

SK Patro, NK Panda, M Sharma - Drug Repurposing for Emerging …, 2023 - Springer
The specialty of otolaryngology and head and neck surgery involves various subspecialties,
encompassing clinical conditions ranging from medical to surgical issues in infections …