Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

Aging is associated with a loss of sex hormone in both men (andropause) and women
(menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone …

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …

Background Testosterone supplementation has been shown to increase muscle mass and
strength in healthy older men. The safety and efficacy of testosterone treatment in older men …

Background. Muscle impairment is a common condition in older people and a powerful risk
factor for disability and mortality. The aim of this study was to apply the European Working …

Objective Men with the metabolic syndrome (MetS) have low plasma testosterone (T) levels.
The aim of this study was to establish whether the normalization of plasma T improves the …

Background. Multimorbidity increases with aging, but risk factors beyond age are unknown.
Objective. To investigate the association of inflammatory and anabolic hormonal biomarkers …

Chronic stress can affect human health through a myriad of behavioral and biochemical
pathways. This review focuses on some key hormonal and metabolic pathways that appear …

Aims Although the association of low serum testosterone levels with mortality has gained
strength in recent research, there are few population-based studies on this issue. This study …

Introduction The circulation of large amounts of dehydroepiandrosterone (DHEA) and its
sulfated derivative (DHEA‐S) suggests a physiological role in human physiology. In the …