Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel
source and also serve as metabolic regulators through FA signaling mediated by membrane …

In the last decade, emerging evidence has reported correlations between the gut
microbiome and human health and disease, including those affecting the brain. We …

Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and
cellular metabolism is emerging as a potential driver of cell fate conversions,,–. How these …

Neural stem/progenitor cells (NSPCs) generate new neurons throughout adulthood.
However, the underlying regulatory processes are still not fully understood. Lipid …

Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a
pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …