STAT3, a master regulator of anti-tumor immune response

C Rébé, F Ghiringhelli - Cancers, 2019 - mdpi.com
Immune cells in the tumor microenvironment regulate cancer growth. Thus cancer
progression is dependent on the activation or repression of transcription programs involved …

Activation of STAT3 and STAT5 signaling in epithelial ovarian cancer progression: mechanism and therapeutic opportunity

CJ Wu, V Sundararajan, BC Sheu, RYJ Huang, LH Wei - Cancers, 2019 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic malignancies. Despite
advances in surgical and chemotherapeutic options, most patients with advanced EOC have …

Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species

J Klughammer, D Romanovskaia, A Nemc… - Nature …, 2023 - nature.com
Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

The evolution of two transmissible cancers in Tasmanian devils

MR Stammnitz, K Gori, YM Kwon, E Harry, FJ Martin… - Science, 2023 - science.org
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …

Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma

H Sorger, S Dey, PA Vieyra‐Garcia… - EMBO Molecular …, 2022 - embopress.org
Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐
homing mature T‐cells causing severe symptoms and high mortality through chronic …

Divergent hepaciviruses, delta-like viruses, and a chu-like virus in Australian marsupial carnivores (dasyurids)

E Harvey, JCO Mifsud, EC Holmes, JE Mahar - Virus Evolution, 2023 - academic.oup.com
Although Australian marsupials are characterised by unique biology and geographic
isolation, little is known about the viruses present in these iconic wildlife species. The …

A transmissible cancer shifts from emergence to endemism in Tasmanian devils

AH Patton, MF Lawrance, MJ Margres, CP Kozakiewicz… - Science, 2020 - science.org
INTRODUCTION Emerging infectious diseases pose one of the greatest threats to human
health and biodiversity. Phylodynamics is an effective tool for inferring epidemiological …

Cantharidin treatment inhibits hepatocellular carcinoma development by regulating the JAK2/STAT3 and PI3K/Akt pathways in an EphB4-dependent manner

M Zhu, X Shi, Z Gong, Q Su, R Yu, B Wang… - Pharmacological …, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. The
tyrosine kinase receptor EphB4 promotes oncogenesis and tumor development and …

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

YM Kwon, K Gori, N Park, N Potts, K Swift, J Wang… - PLoS …, 2020 - journals.plos.org
Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian
devil. The expansion of DFT1 across Tasmania has been documented, but little is known of …

Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world

MEB Ohmer, D Costantini, GÁ Czirják… - Conservation …, 2021 - academic.oup.com
Ecoimmunology is a rapidly developing field that explores how the environment shapes
immune function, which in turn influences host–parasite relationships and disease …