Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Aging is a normal physiological process accompanied by cognitive decline. This aging
process has been the primary risk factor for development of aging-related diseases such as …

Conclusions Substantial evidence indicates that brain BDNF signaling through the TrkB
receptor deteriorates in the AD brain already at an early stage of the disease. Human …

We perform a large-scale meta-analysis of 51 peer-reviewed 3xTg-AD mouse publications
to compare Alzheimer's disease (AD) quantitative clinical outcome measures, including …

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …

Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …

Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a
significant cause of mortality around the world. On a molecular level, the condition is …

Insulin-degrading enzyme (IDE) is a major enzyme responsible for insulin degradation. In
addition to insulin, IDE degrades many targets including glucagon, atrial natriuretic peptide …

Abstract Rationale Intracerebroventricular (ICV) streptozotocin (STZ) mimics sporadic
Alzheimer's disease (SAD) characterized by tau pathology and neurodegeneration arising …

Brain-derived neurotrophic factor (BDNF), or abrineurin, is a member of the neurotrophin
family of growth factors that acts on both the central and peripheral nervous systems. BDNF …