Drugs targeting DNA repair have developed rapidly in cancer therapy, and numerous
inhibitors have already been utilized in preclinical and clinical stages. To optimize the …

Cancer represents a leading cause of death, despite the rapid progress of cancer research,
leading to urgent need for accurate preclinical model to further study of tumor mechanism …

Background The determinants of metastasis in mismatch repair deficiency with high levels of
microsatellite instability (MSI-H) in colorectal cancer (CRC) are poorly understood. Here, we …

Background & Aims Patients with colon cancer with liver metastases may be cured with
surgery, but the presence of additional lung metastases often precludes curative treatment …

Exploring the impact of MMR status in locally advanced Rectal Carcinoma: Insights into
prognosis and treatment outcomes Bobbie-Louise van Emst (6377009) MSc student Drug …