Tyrosine phosphorylation and dephosphorylation of proteins play a critical role for many T‐
cell functions. The opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine …

While the Src family of protein tyrosine kinases (SFK), and the main ancillary molecules
involved in their regulation, have been studied for many years, the details of their interplay …

The lipid raft hypothesis proposes lateral domains driven by preferential interactions
between sterols, sphingolipids, and specific proteins as a central mechanism for the …

A healthy immune system results from a balance of stimulatory and inhibitory pathways that
allow effective responses to acute insults, without descending into chronic inflammation …

Signalling through multichain immunoreceptors is required for the development, activation
and differentiation of haematopoietic cells. One of the most challenging questions with …

In mass spectrometry-based proteomics, frequently hundreds of thousands of MS/MS
spectra are collected in a single experiment. Of these, a relatively small fraction is …

The molecular events and the protein components that are involved in signalling by the T
cell receptor (TCR) for antigen have been extensively studied. Activation of signalling …

The src family kinases p56lck (Lck) and p59fyn (Fyn) are the most proximal signaling
molecules to be activated downstream of the T-cell receptor. Using an inducible transgenic …

Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological
responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as …

T cell signaling begins with the ligation of the T cell antigen receptor (TCR) by a cognate
peptide and the phosphorylation of the receptor's immunoreceptor tyrosine-based activation …