Several interventions, such as ischemic preconditioning, remote pre/perconditioning, or
postconditioning, are known to decrease lethal myocardial ischemia-reperfusion injury …

Multiple studies have highlighted the crucial role of mitochondrial bioenergetics in
understanding the progression of cardiorenal diseases, revealing new potential treatment …

Aging is associated with cardiac hypertrophy and progressive decline in heart function. One
of the hallmarks of cellular aging is the dysfunction of mitochondria. These organelles …

Estrogen deficiency reduces estrogen receptor-alpha (ERα) and promotes apoptosis in the
hippocampus, inducing learning-memory deficits; however, underlying mechanisms remain …

Background: Estrogen deficiency contributes to the development of Alzheimer's disease
(AD) in menopausal women. In the current study, we examined the impact of estrogen …

Background Ischemia-reperfusion (I/R) injury is the most common cause of acute kidney
injury (AKI). Numerous therapeutic approaches for I/R injury have been studied, including …

Background and aim Phytoestrogens are traditionally used for cardiovascular risks but direct
effects on the ischemic heart remain unclear. Plants with phytoestrogens are used for …

Estrogen (E2) deficiency is a risk factor for cardiovascular disease (CVD), however, the
exact mechanism for the E2 protective effect on CVD remains unclear. This study aimed to …

Background and aims Hemorrhagic shock-resuscitation (HSR) following trauma contributes
to organ dysfunction by causing ischemia–reperfusion injury (IRI). We previously showed …

Both advancing age and estrogen loss exacerbate acute myocardial infarction in the female
heart. However, the mechanistic underpinnings of age-related differences in cell death after …