Chalcone: a privileged structure in medicinal chemistry

C Zhuang, W Zhang, C Sheng, W Zhang, C Xing… - Chemical …, 2017 - ACS Publications
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions

Y Wang, DM Du - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
The oxa-Michael cascade reaction, as an important part of the Michael reaction, has also
been significantly developed over the recent decade. This is because the problem of the …

Recent advances in asymmetric organocatalyzed conjugate additions to nitroalkenes

DA Alonso, A Baeza, R Chinchilla, C Gómez… - Molecules, 2017 - mdpi.com
The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes
is a very interesting tool for the construction of highly functionalized synthetic building …

Forty years after “Heterodiene syntheses with α, β-unsaturated carbonyl compounds”: enantioselective syntheses of 3, 4-dihydropyran derivatives

G Desimoni, G Faita, P Quadrelli - Chemical reviews, 2018 - ACS Publications
This review is focused on the enantioselective synthesis of 3, 4-dihydropyran derivatives,
whose importance as chiral building blocks in the synthesis of bioactive molecules and …

Chiral thioureas—preparation and significance in asymmetric synthesis and medicinal chemistry

F Steppeler, D Iwan, E Wojaczyńska, J Wojaczyński - Molecules, 2020 - mdpi.com
For almost 20 years, thioureas have been experiencing a renaissance of interest with the
emerged development of asymmetric organocatalysts. Due to their relatively high acidity and …

Recent advances in the transition metal-free synthesis of heterocycles from α, β-unsaturated ketones

KT Ashitha, A Krishna, D Basavaraja… - Organic Chemistry …, 2022 - pubs.rsc.org
Heterocyclic compounds are an inevitable part of our life. These important classes of
molecules have a wide range of applications starting from life-sustaining drugs to …

The synthesis of O/S-heterocycles starting from β-nitrostyrenes: A recent update

C Li, K Yin, X Zhou, F Zhang, Z Shen - Tetrahedron, 2023 - Elsevier
O/S-Based heterocycles have emerged as one of the most important classes of heterocyclic
compounds and have received considerable attention because of their importance as …

Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment

O Pontes, M Costa, F Santos… - European Journal of …, 2018 - Elsevier
Chalcone and chromene derivatives were synthesized in good yield through simple and
effective reactions using innocuous solvents such as water and ethanol and high yielding …

Asymmetric synthesis and bioselective activities of α-amino-phosphonates based on the dufulin motif

G Zhang, G Hao, J Pan, J Zhang, D Hu… - Journal of agricultural …, 2016 - ACS Publications
The asymmetric synthesis of enantiomerically pure α-aminophosphonates with high and
bioselective activities is a challenge. Here, we report that both enantiomers of α …

An unexpected multi-component one-pot cascade reaction to access furanobenzodihydropyran-fused polycyclic heterocycles

J Guo, H Miao, Y Zhao, X Bai, Y Zhu… - Chemical …, 2019 - pubs.rsc.org
An unexpected multi-component one-pot cascade reaction of hydroxyketones with ortho-
hydroxychalcones has been developed to afford an array of new furanobenzopyran-fused …