Systemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy,
immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into …

The association between central nervous (CNS) stimulants used to treat attention deficit
hyperactivity disorder (ADHD) and Raynaud's phenomenon (RP) has received little attention …

Systemic sclerosis (SSc, scleroderma) is a severe disease characterized by peripheral
microcirculation abnormalities manifesting with Raynaud's phenomenon, nailfold …

We provide a practical and up-to-date approach to inform the assessment and management
of patients with RP including guidance on drug initiation and escalation. Calcium channel …

Abstract Background Digital ulcers (DUs) are a major cause of pain and disability in patients
with systemic sclerosis (SSc). The aim of this scoping review was to evaluate the outcome …

Skin ulceration is an important cause of morbidity in systemic sclerosis and can occur at
anytime during disease progression. Incident disease cohorts are important for …

Systemic sclerosis (SSc, scleroderma) is a complex connective tissue disease whose
earliest clinical manifestations are microvascular tone dysregulation and peripheral …

Aim Raynaud phenomenon (RP) and digital ulcers (DUs) represent the most frequent
manifestations in systemic sclerosis (SSc), being signs of severe vasculopathy. Selexipag …

ABSTRACT Introduction Digital ulcers (DUs) are difficult to treat in patients with systemic
sclerosis (SSc) and systemic (ie, pharmacological) therapy is currently considered the …

Multiorgan system inflammation, vascular dysfunction, and fibrosis characterize systemic
sclerosis (SSc). Comanagement of patients with SSc by rheumatologists, pulmonologists …