The neural basis of psychedelic action
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …
perception, cognition and mood. In this review, we focus on the basic neurobiology …
Towards an understanding of psychedelic-induced neuroplasticity
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …
Predicting reactions to psychedelic drugs: A systematic review of states and traits related to acute drug effects
Psychedelic drugs are increasingly being incorporated into therapeutic contexts for the
purposes of promoting mental health. However, they can also induce adverse reactions in …
purposes of promoting mental health. However, they can also induce adverse reactions in …
Psychedelics and neural plasticity: therapeutic implications
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …
attitudes toward them are changing, and scientists are once again investigating the neural …
Psilocybin-induced mystical-type experiences are related to persisting positive effects: a quantitative and qualitative report
DEW McCulloch, MZ Grzywacz, MK Madsen… - Frontiers in …, 2022 - frontiersin.org
Psychedelic drugs such as psilocybin have shown substantial promise for the treatment of
several psychiatric conditions including mood and addictive disorders. They also have the …
several psychiatric conditions including mood and addictive disorders. They also have the …
[HTML][HTML] Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses
E Drummond, W McCulloch, GM Knudsen… - Neuroscience & …, 2022 - Elsevier
Clinical research into serotonergic psychedelics is expanding rapidly, showing promising
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …
[HTML][HTML] Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
MK Madsen, DS Stenbæk, A Arvidsson… - European …, 2021 - Elsevier
The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of
cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor …
cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor …
Sustained effects of single doses of classical psychedelics in humans
GM Knudsen - Neuropsychopharmacology, 2023 - nature.com
The serotonergic classical psychedelics include compounds that primarily activate the
brain's serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca) …
brain's serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca) …
[HTML][HTML] Toward mapping neurobehavioral heterogeneity of psychedelic neurobiology in humans
Precision psychiatry aims to identify markers of interindividual variability that allow for
predicting the right treatment for each patient. However, bridging the gap between molecular …
predicting the right treatment for each patient. However, bridging the gap between molecular …