Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Single-cell genomic technologies enable the multimodal profiling of millions of cells across
temporal and spatial dimensions. However, experimental limitations hinder the …

The increasing availability of large-scale single-cell atlases has enabled the detailed
description of cell states. In parallel, advances in deep learning allow rapid analysis of newly …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

The development of pancreatic islet endocrine cells is a tightly regulated process leading to
the generation of distinct cell types harbouring different hormones in response to small …

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white
adipose tissue (WAT); however, what regulates this process remains unclear. Here, we …

Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …

Allogeneic islet transplantation allows for the re-establishment of glycemic control with the
possibility of insulin independence, but is severely limited by the scarcity of organ donors …