[HTML][HTML] Impact of modeling and simulation on pharmaceutical process development
This paper explores recent advancements and future directions in the application of
modeling and simulation for pharmaceutical process development. As the rising cost of …
modeling and simulation for pharmaceutical process development. As the rising cost of …
Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent
This work presents hybrid modeling of an active pharmaceutical ingredient flow synthesis in
a ring-opening reaction of an epoxide with a Grignard reagent. Conducting this reaction in a …
a ring-opening reaction of an epoxide with a Grignard reagent. Conducting this reaction in a …
Mechanistic insights into amination via nucleophilic aromatic substitution
Extensive kinetic investigations were performed to identify novel reaction pathways and
assess their feasibility to resolve contradictions in the reported understanding of an …
assess their feasibility to resolve contradictions in the reported understanding of an …
A solvent-selection strategy for the hydrogenation reaction inside a tubular-flow reactor through a statistical approach
B Wahyudianto, T Yamaki, N Hara… - Reaction Chemistry & …, 2025 - pubs.rsc.org
Solvent selection is crucial for optimizing reaction outcomes of various reactions. Herein, we
conducted nitrobenzene hydrogenation in a tubular-flow reactor coated with a Pd/TiO2 …
conducted nitrobenzene hydrogenation in a tubular-flow reactor coated with a Pd/TiO2 …
Kinetic Study and Model-Based Design Space Determination for a Drug Substance Flow Synthesis Using an Amination Reaction via Nucleophilic Aromatic …
A kinetic study and model-based design space determination for drug substance flow
synthesis using an amination reaction are presented. A flow experiment was conducted to …
synthesis using an amination reaction are presented. A flow experiment was conducted to …