Nerve guidance conduit development for primary treatment of peripheral nerve transection injuries: A commercial perspective

BJ Parker, DI Rhodes, CM O'Brien, AE Rodda… - Acta Biomaterialia, 2021 - Elsevier
Commercial nerve guidance conduits (NGCs) for repair of peripheral nerve discontinuities
are of little use in gaps larger than 30 mm, and for smaller gaps they often fail to compete …

A systematic review and meta-analysis of nerve gap repair: comparative effectiveness of allografts, autografts, and conduits

J Lans, KR Eberlin, PJ Evans, D Mercer… - Plastic and …, 2023 - journals.lww.com
Background: Ideal nerve repair involves tensionless direct repair, which may not be possible
after resection. Bridging materials include nerve autograft, allograft, or conduit. This study …

Beyond the limiting gap length: peripheral nerve regeneration through implantable nerve guidance conduits

ER Riva, M Özkan, E Contreras, S Pawar… - Biomaterials …, 2024 - pubs.rsc.org
Peripheral nerve damage results in the loss of sensorimotor and autonomic functions, which
is a significant burden to patients. Furthermore, nerve injuries greater than the limiting gap …

Reconstruction of critical nerve defects using allogenic nerve tissue: a review of current approaches

T Kornfeld, A Borger, C Radtke - International journal of molecular …, 2021 - mdpi.com
Regardless of the nerve defect length, nerve injury is a debilitating condition for the affected
patient that results in loss of sensory and motor function. These functional impairments can …

Acellular nerve allografts in major peripheral nerve repairs: An analysis of cases presenting with limited recovery

BR Peters, MD Wood, DA Hunter, SE Mackinnon - Hand, 2023 - journals.sagepub.com
Background: Acellular nerve allografts have been used successfully and with increasing
frequency to reconstruct nerve injuries. As their use has been expanded to treat longer gap …

Repair of long nerve defects with a new decellularized nerve graft in rats and in sheep

E Contreras, S Traserra, S Bolívar, J Forés… - Cells, 2022 - mdpi.com
Decellularized nerve allografts (DC) are an alternative to autografts (AG) for repairing severe
peripheral nerve injuries. We have assessed a new DC provided by VERIGRAFT. The …

Current trends in the reconstruction and rehabilitation of jaw following ablative surgery

JJ Pu, SG Hakim, JC Melville, YX Su - Cancers, 2022 - mdpi.com
Simple Summary The Maxilla and mandible provide skeletal support for of the middle and
lower third of our faces, allowing for the normal functioning of breathing, chewing …

Preparation and assessment of an optimized multichannel acellular nerve allograft for peripheral nerve regeneration

T Yu, Q Ao, T Ao, MA Ahmad, A Wang… - Bioengineering & …, 2023 - Wiley Online Library
Peripheral nerve regeneration after injury is still a clinical problem. The application of
autologous nerve grafting, the gold standard treatment, is greatly restricted. Acellular nerve …

Closing the gap: Bridging peripheral sensory nerve defects with a chitosan-based conduit a randomized prospective clinical trial

A Böcker, M Aman, U Kneser, L Harhaus… - Journal of personalized …, 2022 - mdpi.com
Introduction: If tensionless nerve coaptation is not possible, bridging the resulting peripheral
nerve defect with an autologous nerve graft is still the current gold standard. The concept of …

Biomaterial and therapeutic approaches for the manipulation of macrophage phenotype in peripheral and central nerve repair

A Dervan, A Franchi, FR Almeida-Gonzalez… - Pharmaceutics, 2021 - mdpi.com
Injury to the peripheral or central nervous systems often results in extensive loss of motor
and sensory function that can greatly diminish quality of life. In both cases, macrophage …