Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Preclinical models in head and neck squamous cell carcinoma

P Chaves, M Garrido, J Oliver, E Pérez-Ruiz… - British Journal of …, 2023 - nature.com
Head and neck cancer is the sixth most frequent cancer type. Drug resistance and toxicity
are common challenges of the existing therapies, making the development of reliable …

Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8+ T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells

Y Fang, M Chen, G Li, Y Yang, P He, J Chen, L Cheng… - Cancer Letters, 2022 - Elsevier
The characteristics of fibroblast cells in head and neck precancerous lesion and its ability to
secrete inflammatory cytokines and affect CD8+ T cell functions remain unclear. Herein, we …

AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer

A Aytatli, N Barlak, F Sanli, HO Caglar, B Gundogdu… - Cellular Oncology, 2022 - Springer
Purpose Development of chemoresistance is one of the major obstacles to the treatment of
head and neck squamous cell carcinoma (HNSCC). The PI3K/Akt pathway, involved in drug …

A validated mathematical model of FGFR3‐mediated tumor growth reveals pathways to harness the benefits of combination targeted therapy and immunotherapy in …

K Okuneye, D Bergman, JC Bloodworth… - Computational and …, 2021 - Wiley Online Library
Bladder cancer is a common malignancy with over 80,000 estimated new cases and nearly
18,000 deaths per year in the United States alone. Therapeutic options for metastatic …

[PDF][PDF] Dicer Inhibits Hepatocellular Carcinoma by Inhibiting the Interleukin 6 Pathway

H Ma, N Xing, L Hou, J Wu, Z Sha, F Wang, X Ji… - Hepatitis …, 2023 - brieflands.com
Background: Inflammatory cytokines are related to the occurrence and development of
hepatocellular carcinoma (HCC). Objectives: Interleukin 6 (IL-6) is associated with the …

[HTML][HTML] Mathematical Modeling Turns Cancer Discoveries into Effective Treatments

TL Jackson - siam.org
Unfortunately, the reasoning behind this prediction is sound because “cancer” is the
designation for hundreds of genetically different diseases. Furthermore, a “team-based …

Biodegradable Polylactide-co-Glycolide-Chitosan Janus Nanoparticles for the Local Delivery of Multifaceted Drug Therapy for Oral Squamous Cell Carcinoma …

C Bissonnette - 2020 - rave.ohiolink.edu
Introduction: Risk factor behavior eg smoking with/without alcohol or diseases associated
with DNA repair deficits eg Fanconi anemia (FA) render the entire oral cavity at risk to …

[PDF][PDF] CURRICULUM VITÆ March 10th, 2020 TRACHETTE L. JACKSON

TL JACKSON - 1998 - lsa.umich.edu
This is a documentary project on the new math of the life sciences that was premiered at the
Joint Math Meetings on January 11th, 2013. The movie features leaders in the field of …

[PDF][PDF] CURRICULUM VITÆ October 25th, 2021

TL JACKSON - 1998 - lsa.umich.edu
From the AWM website: The AWM Fellows program recognizes individuals who have
demonstrated a sustained commitment to the support and advancement of women in the …