CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Dent's disease is a renal tubular disorder characterized by manifestations of proximal tubule
dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis …

Proteins of the CLC gene family assemble to homo-or sometimes heterodimers and either
function as Cl–channels or as Cl–/H+-exchangers. CLC proteins are present in all phyla …

Dent disease is a rare genetic proximal tubulopathy which is under-recognized. Its
phenotypic heterogeneity has led to several different classifications of the same disorder, but …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Dent disease is a rare X‐linked tubulopathy characterized by low molecular weight
proteinuria, hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressive renal …

Proteinuria is a well-known risk factor, not only for renal disorders, but also for several other
problems such as cardiovascular diseases and overall mortality. In the kidney, the chloride …

Key points The reabsorptive activity of renal proximal tubule cells is mediated by receptor‐
mediated endocytosis and polarized transport systems that reflect final cell differentiation …

Dent's disease is an X-linked recessive disorder affecting the proximal tubules. Mutations in
the 2Cl−/H+ exchanger ClC-5 gene CLCN5 are frequently associated with Dent's disease …

Dent disease is an X-linked tubulopathy frequently caused by mutations in the CLCN5 gene
encoding the voltage-gated chloride channel and chloride/proton antiporter, ClC-5. About …