Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
Mammalian ceramide synthases
M Levy, AH Futerman - IUBMB life, 2010 - Wiley Online Library
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …
DNA replication fork speed underlies cell fate changes and promotes reprogramming
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …
characterized. In the present study, we employed DNA fiber analysis to investigate how …
DNA replication timing
N Rhind, DM Gilbert - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …
structure, and genome evolution. Recent advances in genome-scale mapping of replication …
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types
To identify evolutionarily conserved features of replication timing and their relationship to
epigenetic properties, we profiled replication timing genome-wide in four human embryonic …
epigenetic properties, we profiled replication timing genome-wide in four human embryonic …
Sequencing newly replicated DNA reveals widespread plasticity in human replication timing
RS Hansen, S Thomas, R Sandstrom… - Proceedings of the …, 2010 - National Acad Sciences
Faithful transmission of genetic material to daughter cells involves a characteristic temporal
order of DNA replication, which may play a significant role in the inheritance of epigenetic …
order of DNA replication, which may play a significant role in the inheritance of epigenetic …
Eukaryotic chromosome DNA replication: where, when, and how?
H Masai, S Matsumoto, Z You… - Annual review of …, 2010 - annualreviews.org
DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
A Letessier, GA Millot, S Koundrioukoff, AM Lachagès… - Nature, 2011 - nature.com
Common fragile sites have long been identified by cytogeneticists as chromosomal regions
prone to breakage upon replication stress. They are increasingly recognized to be …
prone to breakage upon replication stress. They are increasingly recognized to be …
High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells
PA Zhao, T Sasaki, DM Gilbert - Genome biology, 2020 - Springer
Background DNA replication in mammalian cells occurs in a defined temporal order during
S phase, known as the replication timing (RT) programme. Replication timing is …
S phase, known as the replication timing (RT) programme. Replication timing is …
Rif1 regulates the replication timing domains on the human genome
S Yamazaki, A Ishii, Y Kanoh, M Oda, Y Nishito… - The EMBO …, 2012 - embopress.org
DNA replication is spatially and temporally regulated during S‐phase. DNA replication
timing is established in early‐G1‐phase at a point referred to as timing decision point …
timing is established in early‐G1‐phase at a point referred to as timing decision point …