Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are
traditionally considered to cause apoptosis in tumor cells and virally infected cells. However …

Granzyme A (GrA) has long been recognized as one of the key players in the induction of
cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells …

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …

Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and
chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet …

If not properly regulated, the inflammatory immune response can promote carcinogenesis,
as evident in colorectal cancer (CRC). Aiming to gain mechanistic insight into the link …

THP-1 monocyte, which can be differentiated into macrophages by PMA, is widely used in
researches on pathogen infection and host innate immunity, but reports on the induction …

Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine
proteases produced by cells of the immune system. Previous studies have indicated that …

Community-acquired pneumonia (CAP) has been brought to the forefront of global health
priorities due to the COVID-19 pandemic. However, classification of viral versus bacterial …

Aims: Peritonitis is one of the most common causes of sepsis, a serious syndrome
characterized by a dysregulated systemic inflammatory response. Recent evidence …

Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed
as a mediator of cell death. However, a growing body of data suggests the physiological role …