Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Minimally invasive and regenerative therapeutics

N Ashammakhi, S Ahadian, MA Darabi… - Advanced …, 2019 - Wiley Online Library
Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging,
microsurgery procedures, and microscale technologies have made minimally invasive …

Regenerative rehabilitation with conductive biomaterials for spinal cord injury

EA Kiyotake, MD Martin, MS Detamore - Acta biomaterialia, 2022 - Elsevier
The individual approaches of regenerative medicine efforts alone and rehabilitation efforts
alone have not yet fully restored function after severe spinal cord injury (SCI). Regenerative …

Extracellular matrix‐mimetic hydrogels for treating neural tissue injury: a focus on fibrin, hyaluronic acid, and elastin‐like polypeptide hydrogels

DW Nelson, RJ Gilbert - Advanced healthcare materials, 2021 - Wiley Online Library
Neurological and functional recovery is limited following central nervous system injury and
severe injury to the peripheral nervous system. Extracellular matrix (ECM)‐mimetic …

Evolution of drug-eluting biomedical implants for sustained drug delivery

JC Quarterman, SM Geary, AK Salem - European Journal of Pharmaceutics …, 2021 - Elsevier
In the field of drug delivery, the most commonly used treatments have traditionally been
systemically delivered using oral or intravenous administration. The problems associated …

Drug-loaded zwitterion-based nanomotors for the treatment of spinal cord injury

T Bao, N Li, H Chen, Z Zhao, J Fan, Y Tao… - … Applied Materials & …, 2023 - ACS Publications
Spinal cord injury (SCI) treatment requires a nanosystem for drug delivery that can
effectively penetrate the blood–spinal cord barrier (BSCB). Herein, we designed poly (2 …

Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …

In Situ Cross-Linkable Hyaluronic–Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury

F Sorouri, P Hosseini, M Sharifzadeh… - … Applied Materials & …, 2023 - ACS Publications
Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar
formation, leading to the inhibition of new axon growth and impaired regeneration …

Assessing the combination of magnetic field stimulation, iron oxide nanoparticles, and aligned electrospun fibers for promoting neurite outgrowth from dorsal root …

JL Funnell, AM Ziemba, JF Nowak, H Awada… - Acta biomaterialia, 2021 - Elsevier
Magnetic fiber composites combining superparamagnetic iron oxide nanoparticles (SPIONs)
and electrospun fibers have shown promise in tissue engineering fields. Controlled grafting …

Application of conductive hydrogels on spinal cord injury repair: a review

NH Shahemi, MM Mahat, NAN Asri… - ACS Biomaterials …, 2023 - ACS Publications
Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term
disabilities due to disruption of electrical conduction in neuronal pathways. Despite current …