This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …

Short read massive parallel sequencing has emerged as a standard diagnostic tool in the
medical setting. However, short read technologies have inherent limitations such as GC …

Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

Adaptive radiation is the likely source of much of the ecological and morphological diversity
of life,,–. How adaptive radiations proceed and what determines their extent remains unclear …

The Illumina DNA sequencing platform generates accurate but short reads, which can be
used to produce accurate but fragmented genome assemblies. Pacific Biosciences and …

Long-read single-molecule sequencing has revolutionized de novo genome assembly and
enabled the automated reconstruction of reference-quality genomes. However, given the …

Several new genomics technologies have become available that offer long-read sequencing
or long-range mapping with higher throughput and higher resolution analysis than ever …

While metagenomics has emerged as a technology of choice for analyzing bacterial
populations, the assembly of metagenomic data remains challenging, thus stifling biological …

Complex allelic variation hampers the assembly of haplotype-resolved sequences from
diploid genomes. We developed trio binning, an approach that simplifies haplotype …

Aegilops tauschii is the diploid progenitor of the D genome of hexaploid wheat (Triticum
aestivum, genomes AABBDD) and an important genetic resource for wheat,,. The large size …