Chronic pain is a significant problem worldwide and is the most common disability in the
United States. It is well known that the immune system plays a critical role in the …

Microglia mediate multiple facets of neuroinflammation. They can be phenotypically divided
into a classical phenotype (pro-inflammatory, M1) or an alternative phenotype (anti …

Methamphetamine (METH) is a highly addictive psychostimulant that causes significant
health issues due to high prevalence of its illegal use. Chronic use of METH is associated …

Peripheral neuropathy is the major dose‐limiting side effect of paclitaxel (PTX), affecting
both the quality of life and the survival of cancer patients. Nab‐paclitaxel (nab‐PTX) was …

Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the
effects of available analgesics, including opioids. Converging evidence indicates the …

Chronic pain is the most prominent and disabling symptom in the patients with osteoarthritis
(OA), and the underlying mechanism largely remains unclear. Interleukin-6 (IL-6), a …

Background and aim Minocycline, a tetracycline derivative, has been found to exert
neuroprotective properties. The current project aimed to assess the antioxidant status and …

Abstract Resolvin D5 (RvD5) is a specialized pro-resolving lipid mediator with potent anti-
inflammatory and analgesic properties. Orofacial pain conditions, especially those that are …

Background Inflammation is a well-known risk factor for depression. Specifically, patients
who do not respond to antidepressant treatment show higher levels of inflammatory …

Background: It is necessary to understand the mechanism of trigeminal neuralgia (TN) and
hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous …