Smart-ORF: a single-molecule method for accessing ribosome dynamics in both upstream and main open reading frames
A Gaba, H Wang, T Fortune, X Qu - Nucleic Acids Research, 2021 - academic.oup.com
Upstream open reading frame (uORF) translation disrupts scanning 43S flux on mRNA and
modulates main open reading frame (mORF) translation efficiency. Current tools, however …
modulates main open reading frame (mORF) translation efficiency. Current tools, however …
Stable m7G Cap-Distal 5′UTR Hairpin Structure Mediates Distinct 40S and 60S Binding Dynamics
H Wang, A Gaba, X Qu - bioRxiv, 2021 - biorxiv.org
ABSTRACT The 5′ untranslated region (UTR) of diverse mRNAs contains secondary
structures that can influence protein synthesis by modulating the initiation step of translation …
structures that can influence protein synthesis by modulating the initiation step of translation …
m7G cap-eIF4E interaction stimulates polysome formation by enhancing first-round initiation kinetics
L Sun, A Gaba, H Wang, X Qu - bioRxiv, 2021 - biorxiv.org
Translation in eukaryotic cells occurs predominantly through a 7-methylguanosine (m7G)
cap-dependent mechanism. m7G cap interactions with eukaryotic initiation factor 4E (eIF4E) …
cap-dependent mechanism. m7G cap interactions with eukaryotic initiation factor 4E (eIF4E) …