Hepatorenal syndrome is a complication of liver cirrhosis with ascites that results from the
complex interplay of many pathogenetic mechanisms. Advanced cirrhosis is characterized …

Bile cast nephropathy (BCN) or cholemic nephropathy (CN) is an acute renal dysfunction,
including acute kidney injury (AKI) in the setting of liver injury. It is a common phenomenon …

Background & Aims Cholemic nephropathy (CN) is a severe complication of cholestatic liver
diseases for which there is no specific treatment. We revisited its pathophysiology with the …

Cholestasis is a severe clinical complication that severely damages the liver. Kidneys are
also the most affected extrahepatic organs in cholestasis. The pivotal role of oxidative stress …

Extracorporeal liver-support therapies remain controversial in critically ill patients, as most
studies have failed to show an improvement in outcomes. However, heterogeneous timing …

Liver failure in the context of acute (ALF) and acute on chronic liver failure (ACLF) is
associated with high mortality in the absence of a liver transplant. For decades, therapeutic …

Cholemic nephropathy (CN) is a recognized cause of acute kidney injury (AKI) in patients
with severe hyperbilirubinemia (sHyb) and jaundice. Pathophysiological mechanisms of CN …

Bile duct obstruction or cholestasis can occur by several diseases or xenobiotics.
Cholestasis and the accumulation of the bile constituents in the liver primarily damage this …

Hepatorenal syndrome (HRS), defined as “functional” renal failure in patients with severe
liver disease, is one of the major complications of cirrhosis and portal hypertension, but can …

Results Significant changes in oxidative stress markers were detected in the BDL group. On
the other hand, it was found that PTX (10, 50, and 100 mg/kg) significantly ameliorated …