Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Thrombus formation is increased under conditions of hypoxia in animal models of
thrombosis and in human populations, but current therapies for thrombosis do not directly …

Tumor cells can “hijack” chemokine networks to support tumor progression. In this context,
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …

The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible
factor (HIF) transcription factors; these play an integral role in the metabolic changes that …

Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Tumors use several strategies to evade the host immune response, including creation of an
immune-suppressive and hostile tumor environment. Tissue hypoxia due to inadequate …

Until recently, inflammatory chemokines were viewed mainly as indispensable “gate
keepers” of immunity and inflammation. However, updated research indicates that cancer …

It has become evident that tumor-induced immuno-suppressive factors in the tumor
microenvironment play a major role in suppressing normal functions of effector T cells …

Human breast tumors contain regions of hypoxia in which cells that are located far from a
functional blood vessel have significantly reduced oxygen concentrations when compared …