Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Background Emerging studies showed curcumin can inhibit glioblastoma and breast cancer
cells via regulating ferroptosis. However, the role of ferroptosis in the inhibitory effect of …

Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from
apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a …

Homocysteine (Hcy) is an amino acid involved in gene methylation. Plasma concentration of
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …

Ferroptosis is a newly described type of programmed cell death and intensively related to
both maintaining homeostasis and the development of diseases, especially cancers …

Purpose EF24, a synthetic analogue of curcumin, was developed as an anti-tumor
compound to induce apoptosis, inhibit proliferation and metastasis in various cancers …