Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Tumor-infiltrating natural killer cells

B Cózar, M Greppi, S Carpentier, E Narni-Mancinelli… - Cancer discovery, 2021 - AACR
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …

The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Natural killer cells: from innate to adaptive features

AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

The broad spectrum of human natural killer cell diversity

AG Freud, BL Mundy-Bosse, J Yu, MA Caligiuri - Immunity, 2017 - cell.com
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …

High-dimensional single-cell analysis identifies organ-specific signatures and conserved NK cell subsets in humans and mice

A Crinier, P Milpied, B Escaliere, C Piperoglou… - Immunity, 2018 - cell.com
Natural killer (NK) cells are innate lymphoid cells (ILCs) involved in antimicrobial and
antitumoral responses. Several NK cell subsets have been reported in humans and mice …

Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation

D Pende, M Falco, M Vitale, C Cantoni… - Frontiers in …, 2019 - frontiersin.org
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

Human NK cells, their receptors and function

L Quatrini, M Della Chiesa, S Sivori… - European journal of …, 2021 - Wiley Online Library
NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of
defense against viral infections and contribute to control tumor growth and metastasis. Their …

[HTML][HTML] NK cells and type 1 innate lymphoid cells: partners in host defense

H Spits, JH Bernink, L Lanier - Nature immunology, 2016 - nature.com
Innate lymphoid cells (ILCs) are effectors and regulators of innate immunity and tissue
modeling and repair. Researchers have identified subsets of ILCs with differing functional …

NK cells are never alone: crosstalk and communication in tumour microenvironments

Y Zhou, L Cheng, L Liu, X Li - Molecular Cancer, 2023 - Springer
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …