Cellular prion protein (PrP C) is a mammalian glycoprotein which is usually found anchored
to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. The precise …

Beyond their clinical use as selective estrogen receptor modulators (SERMs), raloxifene and
tamoxifen have attracted recent attention for their favorable activity against a broad range of …

Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative
diseases caused by the misfolding of the cellular prion protein to an infectious form PrPSc …

Several neurodegenerative diseases such as transmissible spongiform encephalopathies,
Alzheimer's and Parkinson's diseases are caused by the conversion of cellular proteins to a …

Prion diseases are transmissible, familial or sporadic. The prion protein (PrP), a normal cell
surface glycoprotein, is ubiquitously expressed throughout the body. While loss of function of …

Prions, the infectious agents of prion diseases, are abnormal conformational variants of the
host-encoded prion protein (PrPC) and are thought to replicate by template-directed …

The generation and spread of misfolded protein aggregates is common to all Protein
Misfolding Diseases (PMDs) including but not limited to Alzheimer's, Parkinson's and Prion …