The aging population is booming all over the world and arterial aging causes various age-
associated pathologies such as cardiovascular diseases (CVDs). The aorta is the largest …

Fibrosis is an important and essential reparative response to injury that, if left uncontrolled,
results in the excessive synthesis, deposition, remodeling, and stiffening of the extracellular …

Aortic stiffness is a hallmark of cardiovascular disease, but its pathophysiology remains
incompletely understood. This study presents an in-dept characterization of aortic aging in …

Evidence links osteoporosis and cardiovascular disease but the cellular and molecular
mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor …

Hypoxia was proved to enhance the angiogenesis of stem cells. However, the mechanism of
the angiogenic potential in hypoxia-pretreated dental pulp stem cells (DPSCs) is poorly …

Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-
dependent enzymes classically involved in the covalent cross-linking of collagen and …

Extracellular matrix (ECM) is an extracellular tissue structure that, in addition to mechanical
support to the cell, is involved in regulation of many cellular processes, including chemical …

Abstract Lysyl oxidase-like 2 (LOXL2) has been identified as an essential mediator of
extracellular matrix (ECM) remodeling in several disease processes including …

Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD
pathophysiology is often characterized by increased stiffening of the heart muscle due to …

Mammalian cells sense and react to the mechanics of their immediate microenvironment.
Therefore, the characterization of the biomechanical properties of tissues with high spatial …