Medical treatment of acute poisoning with organophosphorus and carbamate pesticides
M Jokanović - Toxicology letters, 2009 - Elsevier
Organophosphorus compounds (OPs) are used as pesticides and developed as warfare
nerve agents such as tabun, soman, sarin, VX and others. Exposure to even small amounts …
nerve agents such as tabun, soman, sarin, VX and others. Exposure to even small amounts …
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning
B Antonijevic, MP Stojiljkovic - Clinical medicine & research, 2007 - Marshfield Clinic
The use of organophosphorus pesticides results in toxicity risk to non-target organisms.
Organophosphorus compounds share a common mode of action, exerting their toxic effects …
Organophosphorus compounds share a common mode of action, exerting their toxic effects …
Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds
M Jokanovic, M Prostran - Current Medicinal Chemistry, 2009 - ingentaconnect.com
During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …
agents used in the medical treatment of poisoning with organophosphorus compounds …
Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning
M Jokanović, MP Stojiljković - European journal of pharmacology, 2006 - Elsevier
This paper reviews the mechanisms of interaction of organophosphorus compounds with
cholinesterases and clinical signs of acute poisoning. Further, we describe the current …
cholinesterases and clinical signs of acute poisoning. Further, we describe the current …
Specification of the structure of oximes able to reactivate tabun‐inhibited acetylcholinesterase
J Cabal, K Kuča, J Kassa - Basic & clinical pharmacology & …, 2004 - Wiley Online Library
The efficacy of various oximes to reactivate acetylcholinesterase phosphorylated by tabun
(O‐ethyl‐N, N‐dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo …
(O‐ethyl‐N, N‐dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo …
A novel, sensitive, reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled …
A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was
developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon …
developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon …
Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data
M Jokanovic - Current Topics in Medicinal Chemistry, 2012 - ingentaconnect.com
During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …
agents used in the medical treatment of poisoning with organophosphorus compounds …
Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium
C Luo, A Saxena, M Smith, G Garcia, Z Radić… - Biochemistry, 1999 - ACS Publications
Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) is a key
objective in the treatment of OP poisoning. This study with native, wild-type, and mutant …
objective in the treatment of OP poisoning. This study with native, wild-type, and mutant …
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun …
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and …
J Kassa, K Kuca, L Bartosova… - Current Organic …, 2007 - ingentaconnect.com
Highly toxic organophosphorus inhibitors of acetylcholinesterase referred as nerve agents
are considered to be among the most dangerous chemical warfare agents. The oximes …
are considered to be among the most dangerous chemical warfare agents. The oximes …