The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Abstract α-Synuclein aggregation is a critical molecular process that underpins the
pathogenesis of Parkinson's disease. Aggregates may originate at synaptic terminals as a …

Nanomedicine-based anti-neuroinflammation strategy has become a promising dawn of
Parkinson's disease (PD) treatment. However, there are significant gaps in our …

Real-time gait monitoring is crucial for neuromuscular diagnosis and rehabilitation of
neuromuscular ailments. However, the existing wearable sensors for gait analysis suffer …

α-Synuclein (α-Syn) aggregation into fibrils with prion-like features is intimately associated
with Lewy pathology and various synucleinopathies. Emerging studies suggest that α-Syn …

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been
widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural …

Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …

While defective α-synuclein homeostasis is central to Parkinson's pathogenesis,
fundamental questions about its degradation remain unresolved. We have developed a …

The 2019 novel coronavirus disease (COVID-19) is an infectious disease that began to
spread globally since 2019. Some COVID-19 patients have neurological complications …

Background and Objectives Orthostatic hypotension (OH) increases dementia risk in
patients with Parkinson disease (PD), although the underlying mechanisms and whether a …