Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …

Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a
suppressor of apoptosis and plays a central role in cell division. Survivin has been …

The GTPase Ran has a key role in nuclear import and export, mitotic spindle assembly and
nuclear envelope formation. The cycling of Ran between its GTP-and GDP-bound forms is …

Survivin's proposed dual role as an apoptosis inhibitor and a mitotic effector positioned it in
the front line of cancer research. Notably, survivin is detected as a cytoplasmic and nuclear …

Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the
GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state …

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression
has been widely demonstrated to occur in various types of cancer. Overexpression of …

Abstract CRM1 (Chromosomal Maintenance 1, also known as Exportin 1) is the major
mammalian export protein that facilitates the transport of large macromolecules including …

Since the discovery of survivin (BIRC5) as a cancer-related molecule by Grazia Ambrosini
and Dario C. Altieri at 1997, our knowledge related to the function of this molecule has been …

Treating cancer through inhibition of nuclear export is one of the best examples of basic
research translation into clinical application. Nuclear export factor chromosomal region …