Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …

Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical
samples remains challenging, especially for super-enhancers. Enhancer activities can be …

The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …

Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …

Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …

Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms
of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene …

Ubiquitination has traditionally been viewed in the context of polyubiquitination that is
essential for marking proteins for degradation via the proteasome. Recent discoveries have …

Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22)
deubitiquitylase to cancer development and progression in a select group of tumor types, but …

At sites of chronic inflammation, epithelial cells are exposed to high levels of reactive oxygen
species and undergo cancer-associated DNA methylation changes, suggesting that …