Breast cancer (BC) is a common malignancy in women, with hormone receptor (HR)-positive
subtype responsible for approximately 70% of cases. Currently, patients with metastatic HR …

Simple Summary Soft tissue sarcomas (STSs) are rare malignant conditions with more than
70 subtypes that are difficult to treat, especially in advanced or metastatic states. Recently …

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) are the mainstay of treatment of hormone
receptor+/human epidermal growth factor receptor 2-patients with advanced breast cancer …

The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play
crucial and partially overlapped functions in solid tumors, in which the different isoforms are …

Cyclin-dependent kinases (CDKs) regulate cell division at multiple levels. Aberrant
proliferation induced by abnormal cell cycle is a hallmark of cancer. Over the past few …

Exosomes are small nanoscale vesicles with a double-layered lipid membrane structure
secreted by cells, and almost all types of cells can secrete exosomes. Exosomes carry a …

Hormone receptor (HR)-positive, HER2-negative tumors represent the most common form of
metastatic breast cancer (MBC), and endocrine therapy has been the mainstay treatment for …

One of the biggest challenges of today's society is cancer, which imposes a significant
financial, emotional and spiritual burden on human life. Breast cancer (BC) is one of the …

A narrative review about CDK4/6 inhibitors in the setting of drug resistance: updates on
biomarkers and therapeutic strategies in breast cancer - PMC Back to Top Skip to main content …

Malignant tumors and central nervous system (CNS) disorders are intricately linked to a
process known as" aberrant cell cycle re-entry," which plays a critical role in the progression …