Transmembrane (TM) helices of integral membrane proteins can facilitate strong and
specific noncovalent protein–protein interactions. Mutagenesis and structural analyses have …

The ability of proteins and enzymes to maintain a functionally active conformation under
adverse environmental conditions is an important feature of biocatalysts, vaccines, and …

We show that amino acid covariation in proteins, extracted from the evolutionary sequence
record, can be used to fold transmembrane proteins. We use this technique to predict …

We introduce a new approach to learning statistical models from multiple sequence
alignments (MSA) of proteins. Our method, called Gremlin (Generative REgularized ModeLs …

These studies demonstrate that CSF-1 and IL-34 are conserved in birds, and uses
evolutionary comparisons to infer structure function relationships among vertebrate animals …

Reliable structure-prediction methods for membrane proteins are important because the
experimental determination of high-resolution membrane protein structures remains very …

The utility of engineering enzyme activity is expanding with the development of
biotechnology. Conventional methods have limited applicability as they require high …

As a whole, integral membrane proteins represent about one third of sequenced genomes,
and more than 50% of currently available drugs target membrane proteins, often cell surface …

Understanding the molecular principles that govern allosteric communication is an important
goal in protein science. One way allostery could be transmitted is via sparse energetic …

Point mutations resulting in the substitution of a single amino acid can cause severe
functional consequences, but can also be completely harmless. Understanding what …