Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate
one tRNA molecule by the cognate amino acid. They are a family of twenty enzymes, one for …

Pelizaeus–Merzbacher disease (PMD) is a rare Mendelian disorder characterised by central
nervous system hypomyelination. PMD typically manifests in infancy or early childhood and …

The leukodystrophies cause severe neurodevelopmental defects from birth and follow an
incurable and progressive course that often leads to premature death. It has recently been …

The unique ecology, pathology and undefined taxonomy of coconut foliar decay virus
(CFDV), found associated with coconut foliar decay disease (CFD) in 1986, prompted …

Background Parthanatos represents a critical molecular aspect of Parkinson's disease,
wherein AIMP2 aberrantly activates PARP-1 through direct physical interaction. Although …

Multi-aminoacyl-tRNA synthetase complex (MSC) is the second largest machinery for
protein synthesis in human cells and also regulates multiple nontranslational functions …

Amino acid ligation to cognate transfer RNAs (tRNAs) is catalyzed by aminoacyl-tRNA
synthetases (aaRSs)—essential interpreters of the genetic code during translation …

In human immunodeficiency virus-1 (HIV-1), reverse transcriptase (RT) is encoded as a 66
kDa protein, p66, in the Gag-Pol polyprotein. This protein is proteolytically cleaved by HIV-1 …

Background An important step in human immunodeficiency virus type 1 (HIV-1) replication is
the packaging of tRNA 3 Lys from the host cell, which plays the role of primer RNA in the …

Replication of human immunodeficiency virus type 1 (HIV-1) requires the packaging of
tRNALys, 3 from the host cell into the new viral particles. The GagPol viral polyprotein …